Tinea corporis intrafamilial infection in pets due to Microsporum canis

Microsporum canis, one of the most widespread dermatophytes worldwide, is a zoonotic microorganism that transmits infection from reservoirs such as cats and dogs to humans. This microorganism is associated with Tinea corporis and other clinical manifestations; however, few studies have used genetic surveillance to determine and characterize the process of zoonotic transmission. In this study, we show a clear example of zoonotic transmission from a cat to an intrafamilial environment, where it caused Tinea corporis by infection with M. canis. Molecular characterization using the b-tubulin gene and Random Amplified Polymorphic DNA analysis made it possible to determine that the six isolates of M. canis obtained in this study belonged to the same genetic variant or clone responsible for reservoir-reservoir or reservoir-human transmission.

KEYWORDS
Microsporum canis ; Tinea corporis ; Dermatophytes; b-tubulin gene; RAPD

Authorship

Karla Yaeko Sierra-Maeda

Study design or conception

Research

Writing

All authors had access to all the raw data in the study and reviewed the relevant raw data on which the results and conclusions of this study are based

All authors have read and approved the published version of the manuscript

Hospital General ‘‘Dr. Manuel Gea González’’, Servicio de Dermatología, Tlalpan, Ciudad de México, MexicoHospital General ‘‘Dr. Manuel Gea González’’MexicoCiudad de México, MexicoHospital General ‘‘Dr. Manuel Gea González’’, Servicio de Dermatología, Tlalpan, Ciudad de México, Mexico

Fernando Martínez-Hernández

Research

All authors had access to all the raw data in the study and reviewed the relevant raw data on which the results and conclusions of this study are based

All authors have read and approved the published version of the manuscript

Hospital General “Dr. Manuel Gea González”, Departamento de Ecología de Agentes Patógenos, Tlalpan, Ciudad de México, MexicoHospital General “Dr. Manuel Gea González”MexicoCiudad de México, MexicoHospital General “Dr. Manuel Gea González”, Departamento de Ecología de Agentes Patógenos, Tlalpan, Ciudad de México, Mexico

https://orcid.org/0000-0002-6140-8398

Roberto Arenas

Study design or conception

Data analysis

All authors had access to all the raw data in the study and reviewed the relevant raw data on which the results and conclusions of this study are based

All authors have read and approved the published version of the manuscript

Hospital General ‘‘Dr. Manuel Gea González’’, Servicio de Micología, Tlalpan, Ciudad de México, MexicoHospital General ‘‘Dr. Manuel Gea González’’MexicoCiudad de México, MexicoHospital General ‘‘Dr. Manuel Gea González’’, Servicio de Micología, Tlalpan, Ciudad de México, Mexico

https://orcid.org/0000-0002-2992-9564

Leticia Boeta-Ángeles

Data analysis

All authors had access to all the raw data in the study and reviewed the relevant raw data on which the results and conclusions of this study are based

All authors have read and approved the published version of the manuscript

Hospital Juárez de Mexico, Gustavo A. Madero, Ciudad de México, MexicoHospital Juárez de MexicoMexicoCiudad de México, MexicoHospital Juárez de Mexico, Gustavo A. Madero, Ciudad de México, Mexico

https://orcid.org/0000-0002-9794-0140

Luary Carolina Martínez-Chavarría

Study design or conception

Data analysis

Writing

All authors had access to all the raw data in the study and reviewed the relevant raw data on which the results and conclusions of this study are based

All authors have read and approved the published version of the manuscript

Universidad Nacional Autónoma de México, Facultad de Medicina Veterinaria y Zootecnia, Departamento Patología, Coyoacán, Ciudad de México, MexicoUniversidad Nacional Autónoma de MéxicoMexicoCiudad de México, MexicoUniversidad Nacional Autónoma de México, Facultad de Medicina Veterinaria y Zootecnia, Departamento Patología, Coyoacán, Ciudad de México, Mexico

https://orcid.org/0000-0003-4911-5178

Sonia Fabiola Rodríguez-Colín

Data analysis

All authors had access to all the raw data in the study and reviewed the relevant raw data on which the results and conclusions of this study are based

All authors have read and approved the published version of the manuscript

Juan Xicohtencatl-Cortes

Research

Data analysis

All authors had access to all the raw data in the study and reviewed the relevant raw data on which the results and conclusions of this study are based

All authors have read and approved the published version of the manuscript

Hospital Infantil de México Dr. Federico Gómez, Laboratorio de Bacteriología Intestinal, Cuauhtémoc, Ciudad de México, MexicoHospital Infantil de México Dr. Federico GómezMexicoCiudad de México, MexicoHospital Infantil de México Dr. Federico Gómez, Laboratorio de Bacteriología Intestinal, Cuauhtémoc, Ciudad de México, Mexico

https://orcid.org/0000-0003-2577-9973

Rigoberto Hernández-Castro

Study design or conception

Data analysis

Writing

All authors had access to all the raw data in the study and reviewed the relevant raw data on which the results and conclusions of this study are based

All authors have read and approved the published version of the manuscript

https://orcid.org/0000-0002-5656-0942

Correspondence to: Rigoberto Hernandez-Castro General Hospital “Dr. Manuel Gea Gonzalez”, Departamento de Ecología de Agentes Patógenos, Calzada de Tlalpan, 4800, Tlalpan 14080, Mexico City, Mexico Tel: +52 55 40003000 E-mail:rigo37@gmail.com; rhc@unam.mx

CONFLICT OF INTERESTS

The authors declare to have no potential conflicts of interest related to the research, authorship, and/or publication of this article.

SCIMAGO INSTITUTIONS RANKINGS

Figures

Figures (3)

Thumbnail

Figure 1
Erythematous and scaly round multifocal coalescent plaques on the chest, back, and face.

Thumbnail

Figure 2
Bayesian phylogenetic tree using a partial sequence of the b-tubulin gene for Microsporum canis. The numbers of the nodes indicate the values of support or posterior probability. Samples obtained in this study are indicated in bold and by arrows.

Thumbnail

Figure 3
RAPD profiles were obtained using OPE-18 primer. All of them showed the same band pattern. Agarose gel electrophoresis of the amplified fragments. Lane 1: Molecular size marker 1 Kb Plus DNA ladder; Lane 2: M. canis GEA-29 OL660657; Lane 3: M. canis GEA-30 OL660658; Lane 4: M. canis GEA-31 OL660659; Lane 5: M. canis GEA-32 OL660660; Lane 6: M. canis GEA-33 OL660661; Lane 7: M. canis GEA-34 OL660662; Lane 8: Negative control.

Figure 1 Erythematous and scaly round multifocal coalescent plaques on the chest, back, and face.

Figure 2 Bayesian phylogenetic tree using a partial sequence of the b-tubulin gene for Microsporum canis. The numbers of the nodes indicate the values of support or posterior probability. Samples obtained in this study are indicated in bold and by arrows.

Figure 3 RAPD profiles were obtained using OPE-18 primer. All of them showed the same band pattern. Agarose gel electrophoresis of the amplified fragments. Lane 1: Molecular size marker 1 Kb Plus DNA ladder; Lane 2: M. canis GEA-29 OL660657; Lane 3: M. canis GEA-30 OL660658; Lane 4: M. canis GEA-31 OL660659; Lane 5: M. canis GEA-32 OL660660; Lane 6: M. canis GEA-33 OL660661; Lane 7: M. canis GEA-34 OL660662; Lane 8: Negative control.

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Tinea corporis intrafamilial infection in pets due to Microsporum canis

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[1] Correspondence to: Rigoberto Hernandez-Castro General Hospital “Dr. Manuel Gea Gonzalez”, Departamento de Ecología de Agentes Patógenos, Calzada de Tlalpan, 4800, Tlalpan 14080, Mexico City, Mexico Tel: +52 55 40003000 E-mail:rigo37@gmail.com; rhc@unam.mx