Evaluation of dental material series from patients with dental prostheses and suspicion of delayed hypersensitivity

Yoshimura, Fernanda Cortinhas; Cunha, Victor do Espirito Santo; Hahnstadt, Ruppert Ludwig; Pires, Mário Cezar

doi:10.1590/abd1806-4841.20164116

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Investigation • An. Bras. Dermatol. 91 (2) • Mar-Apr 2016 • https://doi.org/10.1590/abd1806-4841.20164116 copy

Evaluation of dental material series from patients with dental prostheses and suspicion of delayed hypersensitivity^* * Study performedat Clínicas de Dermatologia e de Alergia do Hospital do Servidor Público Estadual de São Paulo – São Paulo (SP), Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract:

BACKGROUND:

Patients with oral sensitivity are common in our practice. Allergic contact dermatitis is one of the most frequent etiologies.

OBJECTIVES:

Evaluate oral contact dermatitis using the Brazilian standard series and complementary dental series in patients using dental prostheses, with or without oral complaints. Determine specific dental Brazilian series.

METHODS:

Patients using dental prostheses with or without oral complaints realized patch tests. Brazilian standard series and complementary dental series were used according to ICDRG recommendations. The results were analysed according to age, sex, race, atopic conditions and symptoms associated.

RESULTS:

From 54 patients tested, 34 (63%) were positive at least to one substance. Nineteen had oral complaints, such as burning mouth, itch or oral erythema. There was no association between atopic condition and tests results. Without the oral series, just 23(42,6%) patients had a positive result. Using the Brazilian standard series with the complementary dental series we improved the positivity of the patch test to 47%.

CONCLUSION:

In patients using prostheses and with oral complaints, patch tests with Brazilian standard series with complementary dental series improve the tests positivity.

Keywords:
Dental prosthesis; Hypersensitivity; Patch tests; Prostheses and implants; Skin tests

Nº	Substance	Concentration and vehicle
1	Anthraquinone	Petrolatum2%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 2	Balsam Peru	Petrolatum25%
3	PPD(MIX)	Petrolatum0,4%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 4	Hydroquinone	Petrolatum1%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 5	Potassium dichromate	Petrolatum0,5%
6	Propylene glycol	Petrolatum10%
7	Para- tertiary-butylphenol	Petrolatum1%
8	Neomycin	Petrolatum20%
9	Irgasan	Petrolatum1%
10	Kathon CG	Petrolatum0,5%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 11	Cobalt chloride	Petrolatum1%
12	Lanolin	Petrolatum30%
13	Tiuram(MIX)	Petrolatum1%
14	Ethylenediamine	Petrolatum1%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 15	Perfume (MIX)	Petrolatum7%
16	Mercapto (MIX)	Petrolatum2%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 17	Benzocaine	Petrolatum5%
18	Quaternium 15	Petrolatum0,5%
19	Quinoline(MIX)	Petrolatum6%
20	Nitrofurazone	Petrolatum1%
21	Paraben(MIX)	Petrolatum15%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 22	Epoxy resin	Petrolatum1%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 23	Thimerosal	Petrolatum0,05%
24	Turpentine	Petrolatum10%
25	Carba(MIX)	Petrolatum3%
26	Promethazine	Petrolatum1%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 27	Nickel sulphate	Petrolatum5%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 28	Colophonium	Petrolatum20%
29	Paraphenylenodiamine	Petrolatum1%
^* * Substances of the Brazilian standard series used in dental materials (material kindly provided by FDA-Allergenic Laboratory). 30	Formaldehyde	Water1%
^ Complementary dental series substances.	Mercury	Petrolatum0,5%
^ Complementary dental series substances.	Eugenol	Petrolatum2%
^ Complementary dental series substances.	Methyl methacrylate solid	Petrolatum2%
^ Complementary dental series substances.	Methyl methacrylate	Petrolatum2%
^ Complementary dental series substances.	Vanillin	Petrolatum10%
^ Complementary dental series substances.	Ammonium sulfate	Petrolatum2,5%
^ Complementary dental series substances.	Benzoyl peroxide	Petrolatum1%
^ Complementary dental series substances.	Vanillin (alcoholic extract)	Petrolatum10%

	Positive	Oral complaints
Allergens	N %	N %
Balsam Peru 25%	2 2.89%	1 3.12%
Thimerosal 0.05%	10 14.49%	6 18.75%
Cobalt Chloride1%	4 5.79%	2 6.25%
Potassium dichromate0.5%	2 2.89%	0 -
Nickel sulfate 2.5%	10 14.49%	5 15.63%
Colophonium20%	2 2.89%	2 6.25%
Epoxy resin1%	1 1.44%	1 3.12%
Perfume (Mix) 7%	3 4.34%	2 6.25%
Formaldehyde 1%	2 2.89%	0 -
Benzocaine 5%	2 2.89%	0 -
Hydroquinone 1%	0 -	0 -
^* * Complementary dental series substances. Benzoyl peroxide 1%	17 24.63%	6 18.75%
^* * Complementary dental series substances. Vanillin (alcoholic extract) 10%	6 8.69%	3 9.40 %
^* * Complementary dental series substances. Eugenol 2%	3 4.34%	1 3.12%
^* * Complementary dental series substances. Mercury 0.5%	2 2.89%	1 3.12%
^* * Complementary dental series substances. Methyl methacrylate2%	1 1.44%	1 3.12%
^* * Complementary dental series substances. Vanillin 10%	1 1.44%	1 3.12%
^* * Complementary dental series substances. Methyl methacrylate solid 2%	1 1.44%	0 -
^* * Complementary dental series substances. Ammonium sulfate 2.5%	0 -	0 -
Total	69 100%	32 100%

Series	Negative		Positive		P-value
Series	N	%	N	%	P-value
Complementary without BP	42	77.8%	12	22.2%	<0.001
Complementary	33	61.1%	21	38.9%	0.021
Standard/prostheses	31	57.4%	23	42.6%	0.124
Standard/prostheses+Complementary	20	37.0%	34	63.0%	0.007
Standard/prostheses+Complementary without BP	27	50.0%	27	50.0%	1.000

Series	Standard/prostheses+ complementary	Standard/prostheses
Positive	34 (63%)	23 (42.6%)
Negative	20 (37%)	31 (57.4%)
Total	54 (100%)	54 (100%)

	standard/ protheses +complementary	standard/ protheses	Total
(+)	69	38	107
(-)	957	988	1945
Total	1026	1026	2052

Atopy		Yes		No		Total		P-value
Atopy		N	%	N	%	N	%	P-value
Complementary without BP	Negative	20	80%	22	76%	42	78%	0.715
Complementary without BP	Positive	5	20%	7	24%	12	22%
Complementary	Negative	14	56%	19	66%	33	61%	0.474
Complementary	Positive	11	44%	10	34%	21	39%
Standard/prostheses	Negative	13	52%	18	62%	31	57%	0.456
Standard/prostheses	Positive	12	48%	11	38%	23	43%
Standard/prostheses+ Complementary	Negative	8	32%	12	41%	20	37%	0.477
Standard/prostheses+ Complementary	Positive	17	68%	17	59%	34	63%
Standard/prostheses+ Complementary without BP	Negative	12	48%	15	52%	27	50%	0.785
Standard/prostheses+ Complementary without BP	Positive	13	52%	14	48%	27	50%

Oral complaint		Yes		No		Total		P-value
Oral complaint		N	%	N	%	N	%
Complementary without BP	Negative	29	83%	13	68%	42	78%	0.223
Complementary without BP	Positive	6	17%	6	32%	12	22%
Complementary	Negative	23	66%	10	53%	33	61%	0.346
Complementary	Positive	12	34%	9	47%	21	39%
Standard/prostheses	Negative	23	66%	8	42%	31	57%	0.094
Standard/prostheses	Positive	12	34%	11	58%	23	43%
Standard/prostheses+ Complementary	Negative	16	46%	4	21%	20	37%	0.073
Standard/prostheses+ Complementary	Positive	19	54%	15	79%	34	63%
Standard/prostheses+ Complementary without BP	Negative	21	60%	6	32%	27	50%	0.046
Standard/prostheses+ Complementary without BP	Positive	14	40%	13	68%	27	50%

Sociedade Brasileira de Dermatologia Av. Rio Branco, 39 18. and., 20090-003 Rio de Janeiro RJ, Tel./Fax: +55 21 2253-6747 - Rio de Janeiro - RJ - Brazil
E-mail: revista@sbd.org.br

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[1] Mailing address: Fernanda Cortinhas Yoshimura, Rua Pedro de Toledo,1800 - Moema, 04029-000 - São Paulo - SP, Brazil. Email: fe.yoshi@uol.com.br

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Evaluation of dental material series from patients with dental prostheses and suspicion of delayed hypersensitivity* * Study performedat Clínicas de Dermatologia e de Alergia do Hospital do Servidor Público Estadual de São Paulo – São Paulo (SP), Brazil.

Abstract:

BACKGROUND:

OBJECTIVES:

METHODS:

RESULTS:

CONCLUSION:

Evaluation of dental material series from patients with dental prostheses and suspicion of delayed hypersensitivity^* * Study performedat Clínicas de Dermatologia e de Alergia do Hospital do Servidor Público Estadual de São Paulo – São Paulo (SP), Brazil.