SUMMARY

We retrospectively examined 89 patients with presumptive diagnosis of Vogt-Koyanagi-Harada syndrome. Sixty-eight (76.4%) patients were women and 21 (23.6%) men. Mean age was 34 years and 53 (59.6%) were white. Bilateral ocular involvement was observed in all patients. Twenty-five patients (28.1 %) developed type I disease, 36 (40.4%) type 11 and 28 (31.5%) type 111. In the last two groups we found a larger incidence of neurological disturbances when compared with the first group (p < 0.01). The most frequent extraocular manifestations were headache (56.2%), tinnitus (41.6%), dysacusis (28.1%) and alopecia (27.0%). The most frequent ocular findings were "sunset glow fundus'' (65.2%), Dallen-Fuchs nodules (49.4%)), disc hyperemia (48.3%), granulomatous reaction in the anterior segment (48.3%) and serous retina/ detachment (31.5%). Cataract (52.8%) and glaucoma (27.0%) were the most common complications. Of 18 patients whose cerebrospinal jluid was evaluated, 10 (55.6%) showed pleocytosis with lymphocytosis. Ocular ultrasonography was performed in 30 patients and the changes observed were mild vitreous opacities (43.3%), thickening of the sclera, choroid and episclera (26.7%) and retinal detachment (23.3%).

Keywords:
Vogt-Koyanagi-Harada syndrome; Uveitis; Intraocular inflammation