EVALUATION OF POTENCY OF VACCINES AGAINST <i>CLOSTRIDIUM SEPTICUM COMMERCIALIZED</i> IN BRAZIL

Lobato, F.C.F.; Dias, L.D.; Salvarani, F.M.; Martins, N.É.; Nascimento, R.A.P. do; Assis, R.A. de

doi:10.1590/1808-1657v75p2252008

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Comunicação Científica • Arq. Inst. Biol. 75 (2) • Apr-Jun 2008 • https://doi.org/10.1590/1808-1657v75p2252008 copy

EVALUATION OF POTENCY OF VACCINES AGAINST CLOSTRIDIUM SEPTICUM COMMERCIALIZED IN BRAZIL

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Clostridium septicum, a ubiquitous organism, is the main pathogen causing malignant edema. Because of its strong cytotoxic alpha toxin, infections are often lethal. Losses in livestock can be prevented through vaccination with alpha-toxoid vaccines. The antibody response to the C. septicum component of 12 commercial vaccines was evaluated by the mouse serum neutralization test using rabbit and bovine sera. The vaccines coded as T1, T2, T4, T10 and T11 induced titers of alpha antitoxin higher than the minimum test level of 2.5 IU/mL. None of the other vaccines induced the formation of antibodies. The majority of the C. septicum vaccines commercialized in Brazil were unable to induce an immune response as recommended for the control of this product.

KEY WORDS
Vaccine; alpha toxin; Clostridium septicum ; gas gangrene; clostridiosis

Vacina	Composição
T 1	Clostridium chauvoei, Clostridium novyi, C. septicum, Clostridium sordellii, Clostridium perfringens
	tipos C e D
T 2	C. chauvoei, C. novyi, C. septicum, C. sordellii C. perfringens tipos C e D
T 3	C. chauvoei, C. novyi, C. septicum, C. sordellii, C. perfringens tipos C e D, Clostridium botulinum
	tipos C e D
T 4	C. chauvoei, C. novyi, C. septicum, C. sordellii, Clostridium haemolyticum, C. perfringens
	tipos A, B, C e D
T 5¹ 1 Vacinas produzidas pelo mesmo fabricante.	C. chauvoei, C. novyi, C. septicum, C. sordellii, C. perfringens tipos B, C e D
T 6¹ 1 Vacinas produzidas pelo mesmo fabricante.	C. chauvoei, C. novyi, C. septicum, C. sordellii, C. perfringens tipos B, C e D, C. botulinum
	tipos C e D
T 7	C. chauvoei, C. novyi, C. septicum, C. sordellii e C. perfringens tipos B e D
T 8	C. chauvoei; C. novyi; C. septicum; C. sordellii, C. perfringens tipos C e D
T 9	C. chauvoei, C. novyi tipo B, C. septicum, C. sordellii, C. perfringens tipos B, C e D
T 10	C. chauvoei, C. novyi, C. septicum, C. sordellii, C. perfringens tipos B, C e D
T 11	C. chauvoei, C. novyi tipo B, C. septicum, C. sordellii, C. perfringens tipos C e D
T 12	C. chauvoei, C. novyi tipo B, C septicum, C. sordellii
Controle positivo	Toxóide alfa padrão de C. septicum
Controle negativo	Salina estéril a 0,85%

Vacina	Antitoxina alfa (UI/mL)
T1	5
T2	5
T4	2,5
T10	> ou igual a 5
T11	> ou igual a 5
Toxóide padrão	> ou igual a 5

Vacina	Antitoxina alfa (UI/mL)
	Dia 42² 2 Dose reforço da vacina.	Dia 56
Controle positivo	0,1	> ou igual a 5
T1	0,1	5
T2	0,1	5
T4	0,1	2,5
T10	0,1	> ou igual a 5
T11	0,1	> ou igual 5

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