Do handgrip strength and dexterity predict respiratory function in neuromuscular disease?

Safran, Ertugrul; Ozer, Aysel Yildiz; Gurses, Hulya Nilgun

doi:10.1055/s-0042-1758757

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Sumário

Original Article • Arq. Neuro-Psiquiatr. 80 (11) • 2022 • https://doi.org/10.1055/s-0042-1758757 copy

Do handgrip strength and dexterity predict respiratory function in neuromuscular disease?

A força de preensão manual e a destreza predizem a função respiratória em doenças neuromusculares?

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Background

Neuromuscular diseases are acquired or inherited diseases that affect the function of the muscles in our body, including respiratory muscles.

Objective

We aimed to discover more cost-effective and practical tools to predict respiratory function status, which causes serious problems with patients with neuromuscular disease.

Methods

The Vignos and Brooke Upper Extremity Functional Scales were used to evaluate functional status for patient recruitment. The handgrip strength and dexterity of patients were measured using a dynamometer and nine-hole peg test. Respiratory function parameters: forced vital capacity, forced expiratory volume in one second, and peak expiratory flow were evaluated using spirometry.

Results

The mean age of the 30 patients was 11.5 ± 3.79 years old. Significant relationships were found between nine-hole-peg-test scores and respiratory function parameters on both sides. Significant correlations were found between both handgrip strength and respiratory function parameters (p < 0.05). In the linear regression analysis, it was seen that the forced expiratory volume in 1 second, and peak expiratory flow values could be explained in different percentages (p < 0.05).

Conclusions

Handgrip strength and dexterity measurements can be used as indicators for estimating respiratory function parameters in terms of cost and accessibility, although it is known that they will not replace respiratory function tests.

Keywords
Neuromuscular Diseases; Motor Skills; Respiratory Function Tests; Hand Strength

		Mean ± SD
Age (years old)		11.5 ± 3.78
Height (cm)		133.9 ± 33.06
Weight (kg)		39.03 ± 18.41
Vignos stage (n)	I	3
	II	7
	III	11
	IV	5
	V	4
Brooke stage (n)	I	10
	II	7
	III	10
	IV	3
Type of neuromuscular disease		n
Duchenne muscular dystrophy		6
Becker muscular dystrophy		8
Congenital		5
Nonspecific		11

Parameter		Mean ± SD
Handgrip strength (kgf)	Right side	7.74 ± 4.46
	Left side	6.60 ± 4.30
	p-value	< 0.001
Nine-hole peg test (sec)	Right side	30.99 ± 2.33
	Left side	32.84 ± 14
	p-value	0.002
FEV₁ liter		1.54 ± 0.67
FEV_1% (pred)		73 ± 17.71
FVC liter		1.74 ± 0.77
FVC % (pred)		76.30 ± 17.90
FEV₁ / FVC		91.19 ± 14.69
PEF liter		2.58 ± 1.25
PEF % (pred)		64.53 ± 20.57

	FEV₁ L	FEV₁ % (pred)	FVC L	FVC % (pred)	PEF L	PEF % (pred)
Right NHPT	r_s = - 0.272 p = 0.146	r_s = - 0.474 p = 0.008	r_s = - 0.264 p = 0.146	r_s = - 0.160 p = 0.398	r_s = - 0.568 p = 0.001	r_s = - 0.737 p = 0.001
Left NHPT	r_s = - 0.234 p = 0.213	r_s = - 0.484 p = 0.007	r_s = - 0.226 p = 0.230	r_s = - 0.204 p = 0.280	r_s = - 0.550 p = 0.002	r_s = - 0.732 p < 0.001
Right HGS	r_p = 0.580 p = 0.001	r_p = 0.142 p = 0.453	r_p = 0.427 p = 0.02	r_p = 0.121 p = 0.525	r_p = .740 p < 0.001	r_p = 0.390 p = 0.033
Left HGS	r_p = 0.594 p = 0.001	r_p = 0.358 p = 0.174	r_p = 0.465 p = 0.01	r_p = 0.079 p = 0.676	r_p = .766 p < 0.001	r_p = 0.423 p = 0.02

Dependent Variable	Predictors	R	R²	p
FEV 1 liter	Right handgrip strength	0.580	0.336	0.001
	Left handgrip strength	0.594	0.352	0.001
	Right nine-hole peg test	0.266	0.071	0.155
	Left nine-hole peg test	0.229	0.053	0.223
FEV1% (pred)	Right handgrip strength	0.142	0.020	0.956
	Left handgrip strength	0.174	0.030	0.358
	Right nine-hole peg test	0.417	0.174	0.022
	Left nine-hole peg test	0.413	0.170	0.023
PEF liter	Right handgrip strength	0.740	0.548	< 0.001
	Left handgrip strength	0.766	0.586	< 0.001
	Right nine-hole peg test	0.562	0.316	0.001
	Left nine-hole peg test	0.525	0.276	0.003
PEF % (pred)	Right handgrip strength	0.390	0.152	0.033
	Left handgrip strength	0.423	0.179	0.020
	Right nine-hole peg test	0.755	0.570	< 0.001
	Left nine-hole peg test	0.734	0.539	< 0.001

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[1] Address for correspondence Aysel Yildiz Ozer (e-mail: aysel.yildiz@marmara.edu.tr).