A highly efficient and facile method has been described for the synthesis of imidazo[1,2-a]pyridines in good to excellent yields by condensation of the α-haloketones (ArCOCHXR², Ar = C6H5, 4-MeOC6H4, 4-ClC6H4, 2,4-Cl2C6H3; X = Br, Cl; R² = H, CH3) with 2-aminopyridines without the use of any additional catalyst and solvent.
imidazo[1,2-a]pyridines; α-haloketones; 2-aminopyridines; catalyst-free; solvent-free
