Microvasculature failure is expected in sepsis and at higher amine concentrations. Therefore, special attention focused individually on microcirculation is needed. Here, we present that methylene blue can prevent leukocytes from adhering to the endothelium in a rat model of lipopolysaccharide-induced endotoxemia. As hypothesis evidence, an intravital microscopy image is presented.
Keywords:
Methylene Blue; Microcirculation; Microvessels; Endothelium; Lipopolysaccharides
| Abbreviations, Acronyms & Symbols | |
|---|---|
| LPS | = Lipopolysaccharide |
| MB | = Methylene blue |
| Author's Roles & Responsibilities | |
|---|---|
| FLACM | Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved |
| PBD | Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work |
| JMB | Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work |
| PRBE | Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved |
| CB | Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published; agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved |
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