Comparison of Inflammatory Markers between Adult and Pediatric Brucellosis Patients

Tekin, Recep; Aktar, Fesih; Yılmaz, Kamil; Tekin, Salih; Ayaz, Celal

doi:10.1590/0037-8682-0356-2019

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Short Communication • Rev. Soc. Bras. Med. Trop. 53 • 2020 • https://doi.org/10.1590/0037-8682-0356-2019 copy

Comparison of Inflammatory Markers between Adult and Pediatric Brucellosis Patients

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

This study aimed to evaluate and compare with healthy control subjects the levels of indirect inflammatory markers such as mean platelet volume (MPV), platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR) in adults and children with brucellosis.

METHODS:

White blood cell, neutrophil, lymphocyte, and platelet counts, and C-reactive protein (CRP) levels were retrospectively recorded for all participants.

RESULTS:

NLR and neutrophil counts were significantly higher in adult patients compared to those in pediatric patients.

CONCLUSIONS:

Indirect inflammatory markers such as NLR, PLR, MPV, red distribution width, and CRP levels may be helpful for follow-up of brucellosis.

Keywords:
Inflammation; Adult; Child; Brucellosis

	Group 1	Group 2		Group 3	Group 4
	Mean+SD	Mean+SD		Mean+SD	Mean+SD
	or number (%)	or number (%)	p value	or number (%)	or number (%)	p value
	n=137	n=79		n=71	n=60
Demographic features
Age (years)	36.5±15.5	37.3±15.2	0.719	10.9±3.8	10.0±4.2	0.235
Sex
Male	63 (45.7%)	47 (59.5%)	0.056	36 (50.7%)	29 (48.3%)	0.789
Female	74 (53.6%)	32 (40.5%)		35 (49.3%)	31 (51.7%)
Laboratory findings at admission
WBC (K/µL)	8.9±3.2	6.2±2.6	<0.001	8.1±2.8	7.1±2.7	0.056
Neutrophil (10³/µL)	5.0±2.0	3.4±2.0	<0.001	4.3±2.3	3.3±3.1	0.052
Lymphocyte (10³/µL)	2.1±0.9	2.5±0.8	0.001	3.3±1.9	3.4±1.7	0.619
Platelet count (10³/µL)	240±100	250±72	0.407	240±107	302±84	0.001
RDW, %	15.9±2.1	17.6±3.9	<0.001	15.0±5.1	17.9±5.8	<0.001
PDW, %				17.3±1.3	16.8±2.1	0.127
MPV (fl)	8.2±1.7	8.3±1.3	0.758	7.7±1.1	7.7±0.9	0.799
NLR	2.1±1.1	1.9±1.9	0.452	1.4±1.1	1.1±0.9	0.021
PLR	130.6±68.8	106.9±37.9	0.005	87.4±55.8	102.7±48.7	0.101
AST (U/L)	64.4±99.7			83.4±133.7	30.0±12.6	0.003
ALT (U/L)	61.3±110.1			77.9±121.2	16.2±5.8	<0.001

Hematological Variables	Adult patients	Pediatric patients	p value
	Mean+SD	Mean+SD
WBC (K/µL)	8.9±3.2	8.1±2.8	0.026
Neutrophil (10³/µL)	5.0±2.0	4.3±2.3	0.711
Lymphocyte (10³/µL)	2.1±0.9	3.3±1.9	<0.001
Platelet count (10³/µL)	240±100	240±107	0.977
RDW, %	15.9±2.1	15.0±5.1	0.254
MPV (fl)	8.2±1.7	7.7±1.1	0.023
NLR	2.1±1.1	1.4±1.1	0.010
PLR	130.6±68.8	87.4±55.8	0.010
AST (U/L)	64.4±99.7	83.4±133.7	0.248
ALT (U/L)	61.3±110.1	77.9±121.2	0.322
CRP (mg/dl)	3.2±4.9	1.5±3.1	0.011

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[1] Corresponding Author: Dr. Recep Tekin. e-mail:receptekin@yahoo.com