Abstract

INTRODUCTION

This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis.

METHODS

Patients with Leishmania infection were admitted to Júlio Müller University Hospital.

RESULTS

The number of apoptotic cells was higher in the exudative granulomatous reaction. The exudative cellular reaction displayed higher levels of annexin-A1 detection in macrophages and apoptotic cells. The correlation between annexin-A1 detection in apoptotic cells and macrophages was observed in exudative necrotic reaction and exudative necrotic-granulomatous reaction.

CONCLUSIONS:

Our data demonstrate the relevance of annexin-A1 in the regulation of apoptosis and phagocytosis in leishmaniasis.

Keywords:
Cutaneous leishmaniasis; Skin; Macrophage; Apoptosis; Annexin-A1