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Short Communication • Rev. Soc. Bras. Med. Trop. 54 • 2021 • https://doi.org/10.1590/0037-8682-0728-2020   copy

Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.

METHODS:

MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.

RESULTS:

Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).

CONCLUSIONS:

The proportion of mono-SM-resistant TB among new patients was higher.

Keywords:
M. tuberculosis; Drug resistance; Gene mutations; Gene sequencing

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