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Short Communication • Rev. Soc. Bras. Med. Trop. 53 • 2020 • https://doi.org/10.1590/0037-8682-0150-2019   copy

Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District.

METHODS:

Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality.

RESULTS:

Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%).

CONCLUSIONS:

The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment.

Keywords:
Chagas disease; Benznidazole; Drug-related side effects; Adverse reactions

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