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Short Communication • Rev. Soc. Bras. Med. Trop. 56 • 2023 • https://doi.org/10.1590/0037-8682-0654-2021   copy

Association of Tumor Necrosis Factor-α (-G308A) Polymorphism with risk of Upper Gastrointestinal Bleeding from Schistosomiasis in Pernambuco

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Background:

We evaluated the association between polymorphisms in the tumor necrosis factor alpha (TNF-α) (-G308A) gene and upper gastrointestinal bleeding (UGIB) in schistosomiasis.

Methods:

This was a transverse study involving 294 Brazilian patients infected with Schistosoma mansoni.

Results:

The homozygous A/A genotype in TNF-α (-G308A) showed a risk association (prevalence ratio = 1.90, p = 0.008) with UGIB. There was no statistically significant difference in serum TNF-α levels between the clinical groups.

Conclusions:

The polymorphic TNF-α (-G308A) can be a risk factor for UGIB, in addition to being a potentially predictive factor for the severity of UGIB in schistosomiasis.

Keywords:
Schistosoma mansoni; Tumor necrosis factor alpha; Genetic polymorphism; Gastrointestinal hemorrhage

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